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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Chemical Genomics and Proteomics (Hardcover, 2nd edition)
Loot Price: R5,823
Discovery Miles 58 230
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Chemical Genomics and Proteomics (Hardcover, 2nd edition)
Expected to ship within 12 - 19 working days
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Since the publication of the pioneering first edition of Chemical
Genomics and Proteomics more than seven years ago, the area of
chemical genomics has rapidly expanded and diversified to numerous
novel methods and subdisciplines, such as chemical glycomics and
lipidomics. This second edition has been updated to uniquely
reflect this interdisciplinary feature as well as the remarkable
developments that have occurred. The new edition also covers
innovative applications from cell biology to drug discovery to,
more recently, clinical diagnostics and medical practice, which
utilize the concepts of chemical genomics. The text provides an
overview of the strategies and methodologies of chemical genomics,
focusing on emerging technologies and recent applications in the
areas of combination chemical genetics, toxicogenomics, drug
chemical genomics and proteomics, and orthogonal chemical genetics.
It describes the development and application of novel analytical
methods used in lipodomics, such as steroidomics. The book also
discusses biomarker discovery applications of microarray
technologies using DNA, RNA, and protein and glycan arrays.
Chapters cover further applications of biomolecular biomarkers for
disease diagnosis, in small molecule drug R&D, and during
therapeutic use of medicines. These include prognostic, disease
specific, response (surrogate), and toxicity biomarkers. In
addition, the text explores the principles of contemporary systems
biology and genomics in experimental medicine-a new paradigm that
demonstrates a network-oriented view and advanced statistical and
informatics data management, opening the way toward personalized
medicine. Finally, various in silico chemogenomics approaches are
addressed for predicting binding of drug candidates to undesirable
targets, which would help in designing better clinical candidates
with fewer side effects. This new edition benefits a broad range of
readers from industrial and academic researchers in drug discovery,
medicinal chemistry, and molecular and cell biology to physicians
in clinical diagnostics and students in related fields of study.
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