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Books > Science & Mathematics > Chemistry > Physical chemistry > Solid state chemistry
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Solid-Phase Synthesis - A Practical Guide (Hardcover)
Loot Price: R12,907
Discovery Miles 129 070
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Solid-Phase Synthesis - A Practical Guide (Hardcover)
Expected to ship within 10 - 15 working days
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This hands-on reference tool provides the most up-to-date
information needed to synthesize molecules by solid-phase synthesis
(SPS)-employing polymeric support (resins), anchoring linkages
(handles), coupling reagents (activators), and protection schemes.
The volume presents new strategies for creating a wide variety of
compounds invaluable for drug discovery in coming years. Thoroughly
analyzes peptides, DNA, carbohydrates, conjugates of biomolecules,
and small molecules. Written by 35 internationally recognized
authorities, Solid-Phase Synthesis provides experimental procedures
and a literature review for peptides, DNA, PNA, carbohydrates,
peptidomimetics, and small molecule assembly describes the
preparation of solid supports and handles (linkers) as well as
their appropriate incorporation into a synthetic strategy discusses
methods for the construction of more complex peptides: cyclic
(lactam and disulfide), glyco-, phospho-, sulfo- and nucleopeptides
explains the protocols for the preparation of side-chain and
N-alpha protecting groups for amino acids surveys the various
coupling reagents and methods for peptide chain elongation
considers convergent peptide synthesis (fragment condensations)
examines engineering designs for automation details techniques for
the purification and analysis of peptides and combination libraries
and more Containing over 2400 references and more than 300 tables,
drawings, and equations, Solid-Phase Synthesis is an eminently
practical and quick-reference guide for organic, combinatorial, and
medicinal chemists and biochemists; pharmacists, pharmacologists,
and pharmaceutical researchers; molecular and cell biologists;
enzymologists; immunologists; neurobiologists; and graduate and
medical school students in these disciplines.
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