Hyperbranched Polydendrons - A New Macromolecular Architecture (Hardcover, 2015 ed.)

This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles - a research goal that is currently being pursued by several groups around the globe.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	June 2015
First published:	2015
Authors:	Fiona L. Hatton
Dimensions:	235 x 155 x 18mm (L x W x T)
Format:	Hardcover - Cloth over boards
Pages:	260
Edition:	2015 ed.
ISBN-13:	978-3-319-18752-5
Categories:	Books > Professional & Technical > Technology: general issues > Nanotechnology Books > Science & Mathematics > Chemistry > Organic chemistry > Polymer chemistry Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	3-319-18752-X
Barcode:	9783319187525

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