Chemical Linkers in Antibody-Drug Conjugates (ADCs) (Hardcover)

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two -the chemical linker- also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design. Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.

General

Imprint:	Royal Society of Chemistry
Country of origin:	United Kingdom
Series:	Drug Discovery, Volume 81
Release date:	December 2021
First published:	2022
Editors:	Floris van Delft • John M. Lambert
Dimensions:	234 x 156 x 35mm (L x W x T)
Format:	Hardcover - Unsewn / adhesive bound
Pages:	460
ISBN-13:	978-1-83916-263-3
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Chemistry > Organic chemistry > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	1-83916-263-5
Barcode:	9781839162633

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