PEGylation technology and key applications are introduced by this
topical volume. Basic physical and chemical properties of PEG as
basis for altering/improving in vivo behaviour of PEG-conjugates
such as increased stability, improved PK/PD, and decreased
immunogenicity, are discussed. Furthermore, chemical and enzymatic
strategies for the coupling and the conjugate characterization are
reported. Following chapters describe approved and marketed
PEG-proteins and PEG-oligonucleotides as well as conjugates in
various stages of clinical development. The volume closes with
chapters on FDA regulations and EMEA guidelines for these drugs and
general perspectives for future developments.
General
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