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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Kinesins and Cancer (Hardcover, 2015 ed.)
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Kinesins and Cancer (Hardcover, 2015 ed.)
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This interdisciplinary volume collates research work on kinesins
and cancer. Authors attempt to validate members of the kinesin
superfamily as potential targets for drug development in cancer
chemotherapy. The work begins by highlighting the importance of
kinesins, summarising current knowledge and how they are shown to
be crucial for mitosis. Chapters go on to explore how this family
of proteins are emerging as a novel target for chemotherapeutic
intervention and drug development. Readers will learn how kinesins
travel along microtubules to fulfill their many roles in
intracellular transport or cell division. Several compounds that
inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered
Phase I and II clinical trials and are explored in these chapters.
Additional mitotic kinesins are currently being validated as drug
targets, raising the possibility that the repertoire of
kinesin-based drug targets may expand in the future. The book is
suitable as a reference standard for the field of kinesins and
cancer. It will interest those in academia and pharmaceutical
companies, and anyone with an interest in the medical relevance of
these proteins, which cutting edge methodologies are now enabling
us to understand in astonishing detail.
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