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Programmed Cells from Basic Neuroscience to Therapy (Paperback, Softcover reprint of the original 1st ed. 2013)
Loot Price: R4,875
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Programmed Cells from Basic Neuroscience to Therapy (Paperback, Softcover reprint of the original 1st ed. 2013)
Series: Research and Perspectives in Neurosciences, 20
Expected to ship within 10 - 15 working days
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The recent advances in Programming Somatic Cell (PSC) including
induced Pluripotent Stem Cells (iPS) and Induced Neuronal
phenotypes (iN), has changed our experimental landscape and opened
new possibilities. The advances in PSC have provided an important
tool for the study of human neuronal function as well as
neurodegenerative and neurodevelopmental diseases in live human
neurons in a controlled environment. For example, reprogramming
cells from patients with neurological diseases allows the study of
molecular pathways particular to specific subtypes of neurons such
as dopaminergic neurons in Parkinson's Disease, Motor neurons for
Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting
disease-specific molecular signatures in live human brain cells,
opens possibilities for early intervention therapies and new
diagnostic tools. Importantly, once the neurological neural
phenotype is detected in vitro, the so-called "disease-in-a-dish"
approach allows for the screening of drugs that can ameliorate the
disease-specific phenotype. New therapeutic drugs could either act
on generalized pathways in all patients or be patient-specific and
used in a personalized medicine approach. However, there are a
number of pressing issues that need to be addressed and resolved
before PSC technology can be extensively used for clinically
relevant modeling of neurological diseases. Among these issues are
the variability in PSC generation methods, variability between
individuals, epigenetic/genetic instability and the ability to
obtain disease-relevant subtypes of neurons . Current protocols for
differentiating PSC into specific subtypes of neurons are under
development, but more and better protocols are needed.
Understanding the molecular pathways involved in human neural
differentiation will facilitate the development of methods and
tools to enrich and monitor the generation of specific subtypes of
neurons that would be more relevant in modeling different
neurological diseases.
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