Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products (Paperback, Softcover reprint of the original 1st ed. 2001)

1. 1. General 1. 1. 1. Biaryls-Structural and Biosynthetic Variety The biaryl axis is the joint central structural element of a broad variety of structurally (in particular stereochemically) and biosynthetically inter- esting as well as pharmacologically promising natural products. The increasing importance of this challenging class of secondary metabolites, its widespread occurrence, its pharmacological implications, and, in particular, the phenomenon of axial chirality, have so far been largely underestimated, if not neglected. This is reflected by the fact that there is as yet no true comprehensive review on naturally occurring biaryls in the literature. By this article, we do not intend to provide such a fully comprehensive review, but still want to draw the attention of the scientific community on the manifold rewarding facets of this exciting class of natural products, which is rapidly growing now, with more and more sophisticated analytical and synthetic tools becoming available. Natural biaryls occur far more frequently than initially assumed, among them constitutionally symmetric, simple dimeric monoterpenoid biphenyls like I (I) (see Fig. 1), binaphthalenes like (-)-gossypol (2) (2), bianthraquinones like skyrin (3) (3-7), and biaryls with annelated heterocyclic rings like bismurrayafoline-B (4) (8) and desertorin A (Sa) (9, 10), which is-although built up from a single monomeric precursor -constitutionally unsymmetric.

General

Imprint:	Springer-Verlag
Country of origin:	Austria
Series:	Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products, 82
Release date:	November 2013
First published:	2001
Contributors:	G. Bringmann • C. Gunter • M. Ochse • O. Schupp • S. Tasler
Dimensions:	235 x 155 x 17mm (L x W x T)
Format:	Paperback
Pages:	296
Edition:	Softcover reprint of the original 1st ed. 2001
ISBN-13:	978-3-7091-7272-8
Categories:	Books > Medicine > Nursing & ancillary services > Pharmacy / dispensing Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Chemistry > Organic chemistry > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Botany & plant sciences > General Promotions
LSN:	3-7091-7272-1
Barcode:	9783709172728

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