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Selective Activation of Drugs by Redox Processes (Paperback, Softcover reprint of the original 1st ed. 1990)
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Selective Activation of Drugs by Redox Processes (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: NATO Science Series A:, 198
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This Workshop, under the auspices of the NATO Advanced Research
Workshop program, was organised to review the current status of
research into redox-activated compounds particularly bioreductive
drugs, and their applications in various fields of medicine, both
as diagnostic and therapeutic agents. The Workshop brought together
key workers in this currently expanding field of research, i.e.
clinici- ans, pharmacologists, biochemists and molecular
scientists. The programme consisted of several sections including
general review lectures, presentations of laboratory-based and
clinical research, some poster presentations and general "round
table" discussions. The topics ranged from oxygen effects in
biological processes, the nature and function of redox proteins
particularly those involved in drug activation, the bioactivation
of drugs used as sensitizers in radiation oncology, novel
approaches to anti-cancer chemotherapy, anti-bacterial agents,
non-steroidal anti-inflammatory drugs, anti-oxidants and varous
clinical applications of chemical modifiers. G.E. ADAMS A. BRECCIA
E.M. FIELDEN P. WARDMAN v ACKNOWLEDGEMENTS The Organisers
gratefully acknowledge the following for their generous financial
support: ARW-NATO Comune di Fermo, Italy Cas sa di Risparmio di
Fermo Istituto di Scienze Chimiche, Bologna, Italy Pharm. Group
ALFA, r,assermann, Schiapparplli, Italy Sadam Indu~tr ie.-' Pharmex
Corp., Bologna, Italy vii CONTENTS Characteristics of Hypoxic Cells
that Enhance their Susceptibility to Chemical Injury ...
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