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GI Microbiota and Regulation of the Immune System (Hardcover, 2008 ed.)
Loot Price: R4,446
Discovery Miles 44 460
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GI Microbiota and Regulation of the Immune System (Hardcover, 2008 ed.)
Series: Advances in Experimental Medicine and Biology, 635
Expected to ship within 10 - 15 working days
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The idea that the microbial communities within the GI tract have a
profound influence on general human health actually originated with
Russian scientist Elie Metchnikov at the turn of the last century.
Also known as the "father of immunology," Metchnikov believed that
putrefactive bacteria in the gut were responsible for enhancing the
aging process. He theorized that ingestion of healthy bacteria
found in fermented foods could counteract toxic bacteria and was
the key to good health. His theories concerning good bacteria and
health can be found in his treatise "The Prolongation of Life:
Optimistic Studies." These writings prompted Japanese scientist
Minoru Shirota to begin investigation of how fermentative bacteria
improve health. He succeeded in isolating a strain of Lactobacillus
that could survive passage through the intestine, while promoting a
healthy balance of microbes. The "Shirota strain" is still used
today in the fermented beverage Yakult. It is clear from a
commercial standpoint that these ideas have inspired the
development of a probiotic industry, which has expanded greatly in
the U.S. over the past 5-10 years. Likewise, scientific studies
investigating the microbiota and the immune system have increased
significantly in recent years. This increase in research is also
due to advances in technologies that enable the investigation of
large microbial communities, a resurgence in gnotobiotic animal
research, and improved methods for molecular analysis of probiotic
bacterial species. Our interest in this area stems from our
laboratory observations indicating that antibiotics and fungi can
skew microbiota composition and systemic immune responses. Our
initial base of references upon which to develop further hypotheses
concerning the mechanisms involved in microbiota regulation of
immune responses was limited. However, in presenting the research
at national scientific meetings and at universities across the
country, the feedb
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