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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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Microarray Innovations - Technology and Experimentation (Paperback)
Loot Price: R1,893
Discovery Miles 18 930
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Microarray Innovations - Technology and Experimentation (Paperback)
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Total price: R1,913
Discovery Miles: 19 130
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In recent years, high-density DNA microarrays have revolutionized
biomedical research and drug discovery efforts by the
pharmaceutical industry. Their efficacy in identifying and
prioritizing drug targets based on their ability to confirm a large
number of gene expression measurements in parallel has become a key
element in drug discovery. Microarray Innovations: Technology and
Experimentation examines the incredibly powerful nature of array
technology and the ways in which it can be applied to understanding
the genomic basis of disease. Explores a myriad of applications in
use today This volume explores recent innovations in the microarray
field and tracks the evolution of the major platforms currently
used. The international panel of contributors presents a survey of
the past five years' research and advancements in microarray
methods and applications and their usage in drug discovery and
biomedical research. The contributions discuss improvements in
automation (array fabrication and hybridization), new substrates
for printing arrays, platform comparisons and contrasts,
experimental design, and data normalization and mining schemes.
They also review epigenomic array studies, electronic microarrays,
comparative genomic hybridization, microRNA arrays, and mutational
analyzes. In addition, the book provides coverage of important
clinical diagnostic arrays, protein arrays, and neuroscience
applications. Examines improved methodologies As microarrays have
evolved steadily over time from archetypical in-house complementary
DNA (cDNA) arrays to robust commercial oligonucleotide platforms,
there has been a migration to higher density biochips with
increasing content and better analytical methodologies. This
compendium summarizes the vast advances that have been made in this
technology, highlighting the supreme advantages of microarray-based
appro
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