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Voltage-Gated Calcium Channels (Hardcover, 1st ed. 2022)
Loot Price: R5,650
Discovery Miles 56 500
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Voltage-Gated Calcium Channels (Hardcover, 1st ed. 2022)
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Total price: R5,670
Discovery Miles: 56 700
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This book covers the tremendous progress in the current
understanding of the molecular physiology of voltage-gated calcium
channels. This book includes unparalleled insights into structural
features of calcium channels due to X-ray crystallography and
cryo-EM, which in turn yielded critical information into how these
channels function under normal and pathophysiological conditions,
and how they interact with calcium channel therapeutics. The
chapters investigate how, with the advent of high throughput genome
sequencing, numerous mutations in various calcium channel genes
have been identified in patients with neurological, cardiovascular,
neuropsychiatric and other disorders. This is further complemented
through a much larger in vivo toolkit such as knock-out and
knock-in mice. The chapters further discuss the increased
complexity of calcium channel physiology that arises from mRNA
editing and splicing. Finally, the book also provides an overview
of the updated research on calcium channel inhibitors that can be
used both in vivo and in vitro, and which may serve as a spring
board for new calcium channel therapeutics for human disease.
Voltage-Gated Calcium Channels is useful for academic researchers
at all levels in neuroscience, biophysics, cell biology and drug
discovery.
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