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Contemporary Research on Renal Cell Carcinoma - Basic and Clinical Developments (Paperback, Softcover reprint of the original 1st ed. 1994)
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Contemporary Research on Renal Cell Carcinoma - Basic and Clinical Developments (Paperback, Softcover reprint of the original 1st ed. 1994)
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The management of advanced renal cell carcinoma is still
problematic. Surgery, although the therapy of choice for locally
advanced renal tumors, is still controversial as the treatment for
metastases. The role of surgery in the management of patients with
pulmonary, bony, and liver metastasis is one of the subject matters
discussed in this book. Our results with series of patients
undergoing resection of metastases from the lung, bone, and liver
show that surgery may be appropriate in selected patients with a
good performance status, although most of them certainly cannot be
cured by this procedure alone, i.e., in the absence of effective
adjuvant therapies. As recent developments show, new strategies for
immunotherapy of renal cell carcinoma represent a modest advance
over traditional approaches in the treatment of this cancer, such
as chemo- and radiotherapy. Clinical trials employing recombinant
interferon-a and interleukin 2 produced response rates in up to 30%
of patients treated, as evidenced by the European Immunotherapy
Trials Program. The adverse reactions and the lack of efficacy in
the majority of patients warrants the search for new
immunotherapeutic approaches.
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