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Molecular Machines - A Materials Science Approach (Hardcover)
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Molecular Machines - A Materials Science Approach (Hardcover)
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Molecular Machines presents a dynamic new approach to the physics
of enzymes and DNA from the perspective of materials science.
Unified around the concept of molecular deformability-how proteins
and DNA stretch, fold, and change shape-this book describes the
complex molecules of life from the innovative perspective of
materials properties and dynamics, in contrast to structural or
purely chemical approaches. It covers a wealth of topics, including
nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle
of enzymes; supra-molecular constructions with internal stress;
nano-rheology and viscoelasticity; and chemical kinetics, Brownian
motion, and barrier crossing. Essential reading for researchers in
materials science, engineering, and nanotechnology, the book also
describes the landmark experiments that have established the
materials properties and energy landscape of large biological
molecules. Molecular Machines is also ideal for the classroom. It
gives graduate students a working knowledge of model building in
statistical mechanics, making it an essential resource for
tomorrow's experimentalists in this cutting-edge field. In
addition, mathematical methods are introduced in the bio-molecular
context-for example, DNA conformational transitions are used to
illustrate the transfer matrix formalism. The result is a
generalized approach to mathematical problem solving that enables
students to apply their findings more broadly. Molecular Machines
represents the next leap forward in nanoscience, as researchers
strive to harness proteins, enzymes, and DNA as veritable machines
in medicine, technology, and beyond.
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