Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Cancer Immunology and Immunotherapy (Paperback, 2011 ed.)
Loot Price: R5,435
Discovery Miles 54 350
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Cancer Immunology and Immunotherapy (Paperback, 2011 ed.)
Series: Current Topics in Microbiology and Immunology, 344
Expected to ship within 10 - 15 working days
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Total price: R5,455
Discovery Miles: 54 550
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The interplay between tumors and their immunologic microenvironment
is complex, difficult to decipher, but its understanding is of
seminal importance for the development of novel prognostic markers
and therapeutic strategies. The present review discusses
tumor-immune interactions in several human cancers that illustrate
various aspects of this complexity and proposes an integrated
scheme of the impact of local immune reactions on clinical outcome.
Current active immunotherapy trials have shown durable tumor
regressions in a fraction of patients. However, clinical efficacy
of current vaccines is limited, possibly because tumors skew the
immune system by means of myeloid-derived suppressor cells,
inflammatory type 2 T cells and regulatory T cells (Tregs), all of
which prevent the generation of effector cells. To improve the
clinical efficacy of cancer vaccines in patients with metastatic
disease, we need to design novel and improved strategies that can
boost adaptive immunity to cancer, help overcome Tregs and allow
the breakdown of the immunosuppressive tumor microenvironment.
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