Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport (Paperback, Softcover reprint of the original 1st ed. 1991)

In recent years there have been rapid advances in the growth and differentiation of mammalian cells in culture. This has led to increasing use of such in vitro systems in a wide variety of studies on fundamental aspects of cell structure and function, including normal growth and metabolism, mechanisms of differentiation and oncogenesis, mechanisms of protein and membrane synthesis and cell polarity. Recent advances in our ability to grow cells, including human cells, on permeable supports, to generate confluent cellular barriers with the morphological polarity corresponding to their in vivo counterparts has greatly facilitated such studies. In particular these new techniques have led to an increasing interest in the use of cell and tissue culture systems as a means for examining the transport of drugs across epithelial and endothelial barriers. An obvious question is whether these new in vitro methodologies will provide convenient systems that can substitute for and replace animal models. Various research groups both in academia and in the pharmaceutical industry have been investigating these types of methodologies in order to develop convenient well characterized systems that can be used to examine basic aspects of transcellular transport and to evaluate the permeability of drug molecules and delivery systems. Of particular note is use of confluent cell layers to study the transport of large molecules such as peptides and proteins produced through recombinant DNA technology.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	NATO Science Series A:, 218
Release date:	October 2013
First published:	1991
Editors:	Glynn Wilson • S.S. Davis • L. Illum • Alain Zweibaum
Dimensions:	254 x 178 x 21mm (L x W x T)
Format:	Paperback
Pages:	387
Edition:	Softcover reprint of the original 1st ed. 1991
ISBN-13:	978-1-4757-0288-0
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Botany & plant sciences > General Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > General Books > Professional & Technical > Biochemical engineering > Biotechnology > General Promotions
LSN:	1-4757-0288-4
Barcode:	9781475702880

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