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Books > Medicine > Clinical & internal medicine > Gynaecology & obstetrics
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Tumor Prevention and Genetics III (Paperback, 2005 ed.)
Loot Price: R5,836
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Tumor Prevention and Genetics III (Paperback, 2005 ed.)
Series: Recent Results in Cancer Research, 166
Expected to ship within 10 - 15 working days
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Identification of cancer risk factors and potential prevention
strategies have been some of the most important medical and
research contributions to the improvement of public health in the
past half-century (Steele 2003). Und- standing the role of
lifestyle, exposure to endogenous factors and exogenous
environmental factors, and individual genetic and epigenetic
variability have contributed significantly to this effort. Cancer
prevention strategies have been developed based on results of
epidemiologic, preclinical, and clinical studies that have
generated clues for identifying risk factors that may be modulated
by changes in lifestyle, such as smoking cessation or dietary
modification (Greenwald 2002a). In addition, significant progress
in medical interventions involving chemoprevention-a
pharmacological approach to intervention that aims to prevent,
arrest, or reverse either the initiation phase of carcinogenesis or
the progression of premalignant cells-is beg- ning to pay dividends
in reducing risks associated with cancer. Emerging technologies,
identification of biomarkers of risk, and advances in genetics
research also are finding applications in chemoprevention research
that p- mise to speed the acquisition of knowledge on the molecular
and cellular - fects of chemopreventive agents. 2 Lifestyle
Approaches Population studies from the 1950s through the early
1980s provided c- pelling evidence that modifiable lifestyle
choices can either increase or - crease cancer risk. For example,
several landmark epidemiologic studies in the 1950s showed a clear
association between smoking and lung cancer (Wynder and Graham
1950; Levin et al. 1950). In 1964, the U. S.
General
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