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Benzodiazepines - A Handbook. Basic Data, Analytical Methods, Pharmacokinetics and Comprehensive Literature (Paperback, Softcover reprint of the original 1st ed. 1982)
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Benzodiazepines - A Handbook. Basic Data, Analytical Methods, Pharmacokinetics and Comprehensive Literature (Paperback, Softcover reprint of the original 1st ed. 1982)
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To comment at length on the importance of the benzodiazepines seems
superfluous within the scope of this preface. No other class of
active substances has experienced an even approximately compa rable
advance in the past two decades. It is therefore not surprising
that the formerly dominant barbiturates and bromocarbamides have
had to give way in many fields to the benzodiazepines, which now
rank first (Proudfoot and Park 1828]). Closely linked with the
great therapeutic importance of the benzodia zepines are analytical
problems. Detection and the determination of blood levels can be
necessary under therapeutic aspects, for instance in working out
optimally effective levels in the treatment of epileptic conditions
("drug monitoring"), but also in connection with questions at issue
in toxicology and traffic medicine. A toxicological analysis can be
subdivided into the following steps: Detection (identification
including screening) Determination (e. g. blood, plasma or serum
levels) Interpretation of the analytical results. This book is
intended as a contribution to each of these chapters: The part
"Analytical Data" (pp.I-122) gives a comprehensive collec tion of
data, e.g. general and chromatographic data (TLC, GLC) as well as
spectra (UV, IR, MS) of 19 commercial preparations, 23 important
metabolites and 18 hydrolysis derivatives. Information about
biotransformation and the possible formation of aminobenzo phenone
derivatives is also given. The most important analytical methods
are presented in an extensive review on pp.123-204 in order to make
it possible to select the optimum method on the basis of the
essential data."
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