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Drug-Induced Headache (Paperback, Softcover reprint of the original 1st ed. 1988)
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Drug-Induced Headache (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Advances in Applied Neurological Sciences, 5
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M. WILKINSON Patients with frequent or daily headaches pose a very
difficult problem for the physician who has to treat them,
particularly as many patients think that there should be a medicine
or medicines which give them instant relief. In the search for the
compound which would meet this very natural desire, many drugs have
been manufactured and the temptation for the physician is either to
increase the dose of a drug which seems to be, at any rate,
partially effective, or to add one or more drugs to those which the
patient is already taking. Although there have been some references
to the dangers of overdosage of drugs for migraine in the past, it
was not until relatively recently that it was recognized that drugs
given for the relief of headache, if taken injudiciously, may
themselves cause headache. The first drugs to be implicated in this
way were ergotamine and phenazone. In the case of ergotamine
tartrate, the dangers of ergotism were well known as this was a
disorder which had been known and written about for many years. In
the treatment of headache, fully blown ergotism is rare and in
recent years has usually been due to self-medication in doses much
greater than those prescribed although there are a few recorded
cases where toxic amounts have been given.
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