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Pain Control (Hardcover, 2015 ed.)
Loot Price: R6,326
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Pain Control (Hardcover, 2015 ed.)
Series: Handbook of Experimental Pharmacology, 227
Expected to ship within 12 - 17 working days
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This volume addresses neuronal pain mechanisms at the peripheral,
spinal and supraspinal level which are thought to significantly
contribute to pain and which may be the basis for the development
of new treatment principles. Chapters on nociceptive mechanisms in
the peripheral nociceptive system address the concept of
hyperalgesic priming, the role of voltage-gated sodium channels in
different inflammatory and neuropathic pain states, the
hyperalgesic effects of NGF in different tissues and in
inflammatory and neuropathic pain states, and the contribution of
proteinase activated receptors (PAR) to the development of pain in
several chronic pain conditions. Chapters on nociceptive mechanisms
in the spinal cord address the particular role of NO and of glial
cell activation in the generation and maintenance of inflammatory
and neuropathic pain and it discusses the potential role of local
inhibitory interneurons, of the endogenous endocannabinoid system
and the importance of non-neuronal immune mechanisms in opioid
signaling in the control of pain. Furthermore, it is presented how
spinal mechanisms contribute to the expression of peripheral
inflammation.
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