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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Homocysteine in Protein Structure/Function and Human Disease - Chemical Biology of Homocysteine-containing Proteins (Hardcover, 2013 ed.)
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Homocysteine in Protein Structure/Function and Human Disease - Chemical Biology of Homocysteine-containing Proteins (Hardcover, 2013 ed.)
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Excess of homocysteine, a product of the metabolism of the
essential amino acid methionine, is associated with poor health, is
linked to heart and brain diseases in general human populations,
and accelerates mortality in heart disease patients. Neurological
and cardiovascular abnormalities occur in patients with severe
genetic hyperhomocysteinemia and lead to premature death due to
vascular complications. Although it is considered a non-protein
amino acid, studies over the past dozen years have discovered
mechanisms by which homocysteine becomes a component of proteins.
Homocysteine-containing proteins lose their normal biological
function and become auto-immunogenic and pro-thrombotic. In this
book, the author, a pioneer and a leading contributor to the field,
describes up-to date studies of the biological chemistry of
homocysteine-containing proteins, as well as pathological
consequences and clinical implications of their formation. This is
a comprehensive account of the broad range of basic science and
medical implications of homocysteine-containing proteins for health
and disease.
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