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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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RNA Damage and Repair (Hardcover, 1st ed. 2021)
Loot Price: R4,816
Discovery Miles 48 160
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RNA Damage and Repair (Hardcover, 1st ed. 2021)
Expected to ship within 10 - 15 working days
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Ribonucleic acid (RNA) is a macromolecule that plays a central role
in cell physiology: RNA molecules act as intermediates between the
deoxyribonucleic acid (DNA), where genetic information is stored,
and proteins, which perform the necessary functions within the
cell. Traditionally, the structural and functional properties of
RNA are closely linked to gene expression. However, RNA-based
enzymes, called ribozymes, are also involved in catalysis and small
RNAs regulate key cellular processes, such as cell growth,
division, differentiation, aging and death. RNA is a sensitive
macromolecule that can be easily damaged by environmental
conditions (ultraviolet radiation, oxidative stress) and biological
factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore,
cells have developed mechanisms to protect and/or repair RNA
molecules. This book presents an overview of the biology of RNA
damage, protection and repair in prokaryotes and eukaryotes.
Individual chapters cover the expression regulation, enzymology and
physiological role of such systems, and link them to important
human diseases such as cancer and degenerative diseases.
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