From Globular Proteins to Amyloids proposes a model and mechanism
for explaining protein misfolding. Concepts presented are based on
a model originally intended to show how proteins attain their
native conformations. This model is quantitative in nature and
founded upon arguments derived from information theory. It
facilitates prediction and simulation of the amyloid fibrillation
process, also identifying the progressive changes that occur in
native proteins that lead to the emergence of amyloid aggregations.
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