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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Mechanosensitivity and Mechanotransduction (Paperback, 2011 ed.)
Loot Price: R5,608
Discovery Miles 56 080
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Mechanosensitivity and Mechanotransduction (Paperback, 2011 ed.)
Series: Mechanosensitivity in Cells and Tissues, 4
Expected to ship within 10 - 15 working days
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This book presents the latest findings in the field of research of
mechanosensitivity and mechanotransduction in different cells and
tissues. Mechanosensitivity and mechanotransduction of the heart
and vascular cells, in the lung, in bone and joint tissues, in
sensor systems and in blood cells are described in detail. This
Volume focuses on molecular mechanisms of mechanosensitivity and
mechanotransduction via cytoskeleton. Integrin-mediated
mechanotransduction, the role of actin cytoskeleton and the role of
other cytoskeletal elements are discussed. It contains a detailed
description of several stretch-induced signaling cascades with
multiple levels of crosstalk between different pathways. It
contains a description of the role of nitric oxide in regulation of
cardiac activity and in regulation of mechanically gated channels
in the heart. In the heart mechanical signals are propagated into
the intracellular space primarily via integrin-linked complexes,
and are subsequently transmitted from cell to cell via paracrine
signaling. Biochemical signals derived from mechanical stimuli
activate both acute phosphorylation of signaling cascades, such as
in the PI3K, FAK, and ILK pathways, and long-term morphological
modii cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of
mechanical stretch on vascular cells are also discussed. This
Volume highlights the role of mechanotransduction in the lung, in
bone and joint tissues. For the first time mechanosensitivity and
mechanotransduction in blood cells are discussed. It contains new
insights into mechanosensitive K+ channels functioning in mouse B
lymphocytes. This book is a unique collection of reviews outlining
current knowledge and future developments in this rapidly growing
field. Currently, investigations of the molecular mechanisms of
mechanosensitivity and mechanotransduction are focused on several
issues. The majority of studies investigate intracellular signaling
pathways. Knowledge of the mechanisms which underlie these
processes is necessary for understanding of the normal functioning
of different organs and tissues and allows to predict changes,
which arise due to alterations of their environment. Possibly such
knowledge will allow the development of new methods of artificial
intervention and therapies. This book brings up the problem closer
to the experts in related medical and biological sciences as well
as practicing doctors besides just presenting the latest
achievements in the field.
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