Recent advances in understanding the role of protein
dysmetabolism in neurodegeneration was the theme of the Fondation
IPSEN meeting addressing Genotype-Proteotype-Phenotype
relationships. Experts from international laboratories contributed
to the current volume to produce a comprehensive overview of the
role of protein misfolding in neurodegeneration. Links between
genotype and protein characteristics and between proteotype and
clinical phenomenology were discussed across diseases categories.
Progress in understanding the role of abnormalities of protein
metabolism may lead to the identification of biological markers
relevant to disease monitoring and to the development of new
therapeutic agents capable of modifying and ameliorating basic
neurodegenerative mechanisms.
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