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Books > Medicine > Other branches of medicine > Nuclear medicine
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Advances in Stereotactic and Functional Neurosurgery 6 - Proceedings of the 6th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Rome 1983 (Paperback, Softcover reprint of the original 1st ed. 1984)
Loot Price: R1,670
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Advances in Stereotactic and Functional Neurosurgery 6 - Proceedings of the 6th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Rome 1983 (Paperback, Softcover reprint of the original 1st ed. 1984)
Series: Acta Neurochirurgica Supplement, 33
Expected to ship within 10 - 15 working days
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Local interstitial radiation therapy of intrinsic and inaccessible
brain tumors is confronted with two major problems: 1. The
tolerance of normal brain tissue, which is usually involved in
local tumor irradiation, i.e. perifocal white matter edema and
demyelinating effects, is crucial. 2. Data on radiation effects of
implanted radioactive sources on neoplastic tissue, i.e. data on
the radiosensitivity and on the biology of tumors, are still widely
unavailable. In clinical practice the dose with which to achieve a
given volume of tumor necrosis is roughly estimated. This report
deals with the experimental findings of Iodine-125 and Iridium-I92
permanent implants in healthy and neoplastic brain tissue. Our own
experimental findings are correlated with experimental data on
Yttnul11-l)O irradiation from the literature. The study is directed
to collect data on the tolerance non-tumoral brain tissue and to
attempt to establish a dose-response relationship. Morphologic
Changes in the Dog Brain Following Interstitial Iodine-125
Irradiation Iodine-I25 seeds (manufactured by 3 M Company, St.
Paul, M. N.) with an activity of 3.55 mCi were permanently
implanted under stereotactic conditions into the subcortical white
matter of the gyrus coronalis of the left hemisphere in 6 beagle
dogs. One animal with a non-radioactive seed implanted under
similar operative conditions served as a control. The animals were
allowed to survive 25, 46, 71, 94, 248, 368 days, respectively,
after the implantation. The control animal survived 46 days. A
detailed description of the experimental procedure is given
elsewhere 16. 17.
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