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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Cytomegaloviruses (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R2,292
Discovery Miles 22 920
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Cytomegaloviruses (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Current Topics in Microbiology and Immunology, 154
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Named for the enlarged, inclusion-bearing cells characteristic of
infection by these viruses, cytomegaloviruses present a significant
challenge to both microbiologist and immunologist. Although most
primary infections in humans are subclinical, cytomegalovirus can
be associated with a wide spectrum of disease, particularly when
infection occurs in the immuno compromised individual or as a
result of congenital or perinatal infection. Although reinfection
with cytomegalovirus has been demonstrated, most recurrent and
persistent infections result from the reactivation of latent virus.
Cytomegaloviruses, like other members of the Herpesviridae family,
have the capacity to establish latency after a primary infection
but the mechanisms for establishing the nonreplicating but
reactivat able state have not been defined. The factors responsible
for the spectrum of manifestations of cytomegalovirus infection are
largely undetermined but host immunological function, route of
infection, and size of inoculum all contribute to the extent and
severity of disease. Cytomegaloviruses have the largest genomes in
the herpes virus family, approximately 240 kilo base pairs,
providing a potential coding capacity for more than 200 proteins of
which less than one-fourth have been mapped and described. There
are many similarities to other herpes viruses in genome structure
and gene expression; for example, three temporal classes of genes
can be identified as rx (immediate-early), f3 (early), and y (late)
products. The first five chapters of this volume review and
describe recent developments in understanding the trans cription
and regulation of these gene classes.
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