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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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Single-Stranded DNA Binding Proteins - Methods and Protocols (Hardcover, 2012 ed.)
Loot Price: R2,700
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Single-Stranded DNA Binding Proteins - Methods and Protocols (Hardcover, 2012 ed.)
Series: Methods in Molecular Biology, 922
Expected to ship within 18 - 22 working days
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The genomes of cellular organisms are organized as double-stranded
DNA, a structure that must be unwound to provide DNA replication,
recombination, and repair machinery access to genomic information.
However, DNA unwinding comes with inherent risks to genome
stability. To help mediate these risks, bacterial, archael, and
eukaryotic cells have evolved protective ssDNA-binding proteins
(SSBs) that bind ssDNA with high affinity and specificity. SSBs
also aid genome metabolic processes through direct interactions
with key proteins in genome maintenance enzymes. Single-Stranded
DNA Binding Proteins: Methods and Protocols assembles methods
developed for examining the fundamental properties of SSBs and for
exploiting the biochemical functions of SSBs for their use as in
vitro and in vivo reagents. Clearly and concisely organized, the
volume opens with an introduction to the structures and functions
of SSBs, followed protocols for studying SSB/DNA complexes, methods
for studying SSB/heterologous protein complexes, protocols for
interrogating post-translational modifications of SSBs, and
concludes with uses of fluorescently-labeled SSBs for in vitro and
in vivo studies of genome maintenance processes. Written in the
successful Methods in Molecular Biology (TM) series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible protocols, and notes on troubleshooting and avoiding
known pitfalls. Authoritative and easily accessible,
Single-Stranded DNA Binding Proteins: Methods and Protocols
provides a rich introduction for investigators who are interested
in this fascinating family of DNA-binding proteins.
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