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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Forensic DNA Profiling - A Practical Guide to Assigning Likelihood Ratios (Paperback)
Loot Price: R1,421
Discovery Miles 14 210
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Forensic DNA Profiling - A Practical Guide to Assigning Likelihood Ratios (Paperback)
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DNA testing and its forensic analysis are recognized as the "gold
standard" in forensic identification science methods. However,
there is a great need for a hands-on step-by-step guide to teach
the forensic DNA community how to interpret DNA mixtures, how to
assign a likelihood ratio, and how to use the subsequent likelihood
ratio when reporting interpretation conclusions. Forensic DNA
Profiling: A Practical Guide to Assigning Likelihood Ratios will
provide a roadmap for labs all over the world and the next
generation of analysts who need this foundational understanding.
The techniques used in forensic DNA analysis are based upon the
accepted principles of molecular biology. The interpretation of a
good-quality DNA profile generated from a crime scene stain from a
single-source donor provides an unambiguous result when using the
most modern forensic DNA methods. Unfortunately, many crime scene
profiles are not single source. They are described as mixed since
they contain DNA from two or more individuals. Interpretation of
DNA mixtures represents one of the greatest challenges to the
forensic DNA analyst. As such, the book introduces terms used to
describe DNA profiles and profile interpretation. Chapters explain
DNA extraction methods, the polymerase chain reaction (PCR),
capillary electrophoresis (CE), likelihood ratios (LRs) and their
interpretation, and population genetic models-including Mendelian
inheritance and Hardy-Weinberg equilibrium. It is important that
analysts understand how LRs are generated in a probabilistic
framework, ideally with an appreciation of both semicontinuous and
fully continuous probabilistic approaches. KEY FEATURES: * The
first book to focus entirely on DNA mixtures and the complexities
involved with interpreting the results * Takes a hands-on approach
offering theory with worked examples and exercises to be easily
understood and implementable by laboratory personnel * New methods,
heretofore unpublished previously, provide a means to innovate
deconvoluting a mixed DNA profile, assign an LR, and appropriately
report the weight of evidence * Includes a chapter on assigning LRs
for close relatives (i.e., "It's not me, it was my brother"), and
discusses strategies for the validation of probabilistic genotyping
software Forensic DNA Profiling fills the void for labs unfamiliar
with LRs, and moving to probabilistic solutions, and for labs
already familiar with LRs, but wishing to understand how they are
calculated in more detail. The book will be a welcome read for lab
professionals and technicians, students, and legal professionals
seeking to understand and apply the techniques covered.
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