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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA

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The Deeper Genome - Why there is more to the human genome than meets the eye (Paperback) Loot Price: R225
Discovery Miles 2 250
You Save: R97 (30%)
The Deeper Genome - Why there is more to the human genome than meets the eye (Paperback): John Parrington

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The Deeper Genome - Why there is more to the human genome than meets the eye (Paperback)

John Parrington

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List price R322 Loot Price R225 Discovery Miles 2 250 You Save R97 (30%)

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Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

General

Imprint: Oxford UniversityPress
Country of origin: United Kingdom
Release date: September 2017
Authors: John Parrington
Dimensions: 196 x 130 x 22mm (L x W x T)
Format: Paperback
Pages: 368
ISBN-13: 978-0-19-881309-5
Categories: Books > Science & Mathematics > Science: general issues
Books > Science & Mathematics > Science: general issues > Popular science
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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LSN: 0-19-881309-0
Barcode: 9780198813095

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