Epilepsy has afflicted humankind throughout recorded history;
yet, it is only in the last half-century, that significant progress
has been made in our basic understanding of the epileptic brain.
Pivotal advances in drug development and surgical techniques, as
well as the emergence of innovative approaches such as electrical
stimulation of the nervous system, have led to a substantial
reduction in the morbidity and mortality of patients with epilepsy.
At the same time, remarkable developments in neuroscience have
enhanced our understanding of brain structure and function.
Epilepsy: Mechanisms, Models, and Translational Perspectives
incorporates new translational advances that bring epilepsy
therapies from the laboratory bench to the bedside and back again.
It brings together the work of more than 70 of the field s most
respected and cutting-edge researchers and clinicians. In 24
chapters, this extraordinarily comprehensive and current
work:
Offers an overview of the basic anatomic and functional substrates
of seizure genesis and considers novel pathogenic concepts that
have both emerged and been validated experimentally
- Examines antiepileptic drug therapy, including the latest on
molecular targets
- Looks at the state of surgical treatments for epilepsy and
discusses advances in the fields of structural and functional
neuroimaging
- Reviews the variety of nontraditional therapeutic options, such
as the ketogenic diet, the vagus nerve stimulator,
immunomodulators, neurosteroids, herbs, and botanicals
- Investigates neuroendocrine, hormonal, and biobehavioral
factors that influence seizure susceptibility information that can
be incorporated into the design of treatment algorithms on an
individualized basis
- Provides a glimpse of what future epilepsy therapies might look
like, from novel mechanisms of drug delivery to gene and stem-cell
therapies for epilepsy to seizure detection methods, to the
ultimate goal of disease prevention.
The idea for this book was inspired by the editors collective
desire to promote bridging of the so-called translational divide
that is, covering innovative treatment strategies based on
scientific principles that have yet to be tested rigorously in the
clinical setting, but yet may provide practitioners with new and
promising approaches toward epilepsy therapeutics.
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