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Histological Typing of Tumours of the Gallbladder and Extrahepatic Bile Ducts (Paperback, 2nd ed.)
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Histological Typing of Tumours of the Gallbladder and Extrahepatic Bile Ducts (Paperback, 2nd ed.)
Series: WHO. World Health Organization. International Histological Classification of Tumours
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This is a classification of tumours and tumour-like lesions of the
gall- bladder and extrahepatic bile ducts, including the ampulla of
Vater. Although most of the lesions are found in all three sites,
variations in frequency of the histological types occur and will be
noted. The incidence of carcinoma of the gallbladder varies in
different parts of the world. Variation is also found in different
ethnic groups within the same country. In the United States, for
example, carcino- ma of the gallbladder is more common in American
Indians than in Caucasians or in Blacks; the rate among female
American Indians is 21 per 100000 compared with 1.4 per 100000
among Caucasian fe- males. In Latin American countries, the highest
rates are found in Chile, Mexico and Bolivia. In other countries,
such as Japan, the inci- dence rates are intermediate between those
of American Indians and those of Caucasians. Despite certain
features in common, carcinomas of the gallblad- der and carcinomas
of the extrahepatic bile ducts show a number of differences.
Gallbladder carcinomas are usually associated with cholelithiasis
and have a strong female predominance. In contrast, extrahepatic
bile duct carcinomas are seen less often, occur in both sexes with
equal frequency, are usually not associated with choledo-
cholithiasis, produce early biliary obstruction, and are better
differen- tiated histologically as a group. Moreover, they are seen
in patients with primary sclerosing cholangitis and ulcerative
colitis.
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