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The Genetics of Type 2 Diabetes and Related Traits - Biology, Physiology and Translation (Paperback, Softcover reprint of the original 1st ed. 2016)
Loot Price: R5,984
Discovery Miles 59 840
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The Genetics of Type 2 Diabetes and Related Traits - Biology, Physiology and Translation (Paperback, Softcover reprint of the original 1st ed. 2016)
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This book presents the state of the art of type 2 diabetes
genetics, from the process of genetic discovery to its
interpretation and clinical application, and illustrates a model
for other complex human phenotypes.The first section explores
genome-wide association studies, the extension of this method to
less accessible phenotypes and the arrival of next-generation
sequencing. A further section goes beyond genetics to illustrate
how other data sources can help interpret genetic data, such as
leveraging population diversity, the correlation of genetic
associations with physiological measurements, gene expression
modulation, environmental factors and our microbial commensals. The
third section describes advances in elucidating the complex path
from association to function using in-depth sequencing and
functional studies of the cellular and molecular effects of genes
in the loci identified by genetics. The final section links our
current understanding with clinically relevant questions, such as
prediction, interactions with drugs or nutrients, and disease
prevention, and paints a realistic but hopeful vision of the
future.
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