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Handbook of In Vivo Chemistry in Mice - From Lab to Living System (Hardcover)
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Handbook of In Vivo Chemistry in Mice - From Lab to Living System (Hardcover)
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Provides timely, comprehensive coverage of in vivo chemical
reactions within live animals This handbook summarizes the
interdisciplinary expertise of both chemists and biologists
performing in vivo chemical reactions within live animals. By
comparing and contrasting currently available chemical and
biological techniques, it serves not just as a collection of the
pioneering work done in animal-based studies, but also as a
technical guide to help readers decide which tools are suitable and
best for their experimental needs. The Handbook of In Vivo
Chemistry in Mice: From Lab to Living System introduces readers to
general information about live animal experiments and detection
methods commonly used for these animal models. It focuses on
chemistry-based techniques to develop selective in vivo targeting
methodologies, as well as strategies for in vivo chemistry and drug
release. Topics include: currently available mouse models;
biocompatible fluorophores; radionuclides for
radiodiagnosis/radiotherapy; live animal imaging techniques such as
positron emission tomography (PET) imaging; magnetic resonance
imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible
chemical reactions; ligand-directed nucleophilic substitution
chemistry; biorthogonal prodrug release strategies; and various
selective targeting strategies for live animals. -Completely covers
current techniques of in vivo chemistry performed in live animals
-Describes general information about commonly used live animal
experiments and detection methods -Focuses on chemistry-based
techniques to develop selective in vivo targeting methodologies, as
well as strategies for in vivo chemistry and drug release -Places
emphasis on material properties required for the development of
appropriate compounds to be used for imaging and therapeutic
purposes in preclinical applications Handbook of In Vivo Chemistry
in Mice: From Lab to Living System will be of great interest to
pharmaceutical chemists, life scientists, and organic chemists. It
will also appeal to those working in the pharmaceutical and
biotechnology industries.
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