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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Nucleic Acids in Innate Immunity (Paperback)
Loot Price: R2,024
Discovery Miles 20 240
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Nucleic Acids in Innate Immunity (Paperback)
Expected to ship within 12 - 17 working days
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Until recently, innate immunity was regarded as a relatively
nonspecific system designed to engulf and destroy pathogens.
However, new studies show that the innate immune system is highly
developed in its ability to discriminate between self and foreign
entities. Understanding this mechanism can lead to therapeutic
strategies based on manipulation of this previously unexploited
branch of the immune system. Drawing on the research of leading
experts, Nucleic Acids in Innate Immunity provides insight in this
new area of immunology. The book begins by explaining the roles of
nucleic acids in immunity, describing the mechanism of
discrimination based on pattern-recognition receptors (PRRs),
including Toll-like receptors (TLRs), Nod-like receptors (NLR), and
RIG-I-like receptors (RLR). Chapters discuss how these PRRs
recognize and respond to pathogen-associated molecular patterns
(PAMPs) by activating specific signaling pathways. The second
section focuses on the therapeutic applications of immunomodulatory
DNA by manipulating released pathogenic nucleic acids as immune
system stimulants. The book introduces novel therapeutics developed
to prevent or treat infectious diseases, allergic disorders, and
cancer, as well as clearing unnecessary or abnormal host molecules.
The final section addresses how the immune system discriminates
self and non-self RNA. Recent findings that host (self) nucleic
acids are not inert in the immune system beg the question of
exactly what elements within DNA or RNA are recognized by the
innate immune system. Contributions review recent advances to
understand innate immune recognition of nucleic acids and describe
the resulting immune modulation. Providing a comprehensive review
of nucleic acid recognition and regulation by the innate immune
system, this seminal work reveals new directions for future
research in immune modulation.
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