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Structure-Activity Relationships for Development of Neurokinin-3 Receptor Antagonists - Reducing Environmental Impact (Paperback, 1st ed. 2020)
Loot Price: R2,833
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Structure-Activity Relationships for Development of Neurokinin-3 Receptor Antagonists - Reducing Environmental Impact (Paperback, 1st ed. 2020)
Series: Springer Theses
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This book explores the possible development of neurokinin-3
receptor (NK3R) antagonists with reduced environmental impact.
Pharmaceuticals are used to cure diseases and to alleviate symptoms
in humans and animals. However, the stable, bioactive substances
excreted by patients have unfavorable effects on non-target
species. To overcome these disadvantages of these highly stable,
potent substances, drug design to turn off bioactivity after
release into the environment is needed. The book describes the
development of eco-friendly NK3R antagonists by introducing a
labile functional moiety and substituting a scaffold. This resulted
in a novel NK3R antagonist that oxidized into its inactive form
when exposed to air. Further, the book presents an efficient and
easily achievable synthetic method of creating triazolopiperazine
scaffolds, as well as a structure-activity relationship study
involving scaffold hopping for decomposable motifs, which led to a
novel photodegradable NK3R antagonist. Demonstrating that it is
possible to develop compounds that convert into their inactive
forms under environmental conditions, this book is useful for
anyone interested in therapeutic agents with reduced environmental
impact.
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