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Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants - New Vistas In Parkinson's Disease Therapy (Paperback, 2012 ed.) Loot Price: R2,997
Discovery Miles 29 970
Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants - New Vistas In Parkinson's Disease Therapy...

Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants - New Vistas In Parkinson's Disease Therapy (Paperback, 2012 ed.)

Lucyna Antkiewicz-Michaluk, Hans Rommelspacher

Series: Current Topics in Neurotoxicity, 1

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Loot Price R2,997 Discovery Miles 29 970 | Repayment Terms: R281 pm x 12*

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The specific topic, Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants New Perspectives In ParkinsonS Disease Therapy, was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinsons disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): "ss"-carbolines (BCs) and tetrahydroisoquinolines (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.

In this book we are going to summarize, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.

Additionally, the recent results of experimental studies "in vivo" have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease."

General

Imprint: Springer-Verlag New York
Country of origin: United States
Series: Current Topics in Neurotoxicity, 1
Release date: March 2014
First published: 2012
Editors: Lucyna Antkiewicz-Michaluk • Hans Rommelspacher
Dimensions: 235 x 155 x 13mm (L x W x T)
Format: Paperback
Pages: 178
Edition: 2012 ed.
ISBN-13: 978-1-4899-8754-9
Categories: Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
Books > Medicine > Nursing & ancillary services > Pharmacy / dispensing
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
LSN: 1-4899-8754-1
Barcode: 9781489987549

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