|
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
|
Buy Now
Hypocretins - Integrators of Physiological Signals (Paperback, 2005 ed.)
Loot Price: R2,700
Discovery Miles 27 000
|
|
|
Hypocretins - Integrators of Physiological Signals (Paperback, 2005 ed.)
Expected to ship within 18 - 22 working days
|
The first report that rapid eye movements occur in sleep in humans
was published in 1953. The research journey from this point to the
realization that sleep consists of two entirely independent states
of being (eventually labeled REM sleep and non-REM sleep) was
convoluted, but by 1960 the fundamental duality of sleep was well
established including the description of REM sleep in cats
associated with "wide awake" EEG patterns and EMG suppression. The
first report linking REM sleep to a pathology occurred in 1961 and
a clear association of sleep onset REM periods, cataplexy,
hypnagogic hallucinations and sleep paralysis was fully established
by 1966. When a naive individual happens to observe a full-blown
cataplexy attack, it is both dramatic and unnerving. Usually the
observer assumes that the loss of muscle tone represents syncope or
seizure. In order to educate health professionals and the general
public, Christian Guilleminault and I made movies of full-blown
cataplectic episodes (not an easy task). We showed these movies of
cataplexy attacks to a number of professional audiences, and were
eventually rewarded with the report of a similar abrupt loss of
muscle tone in a dog. We were able to bring the dog to Stanford
University and with this as the trigger, we were able to develop
the Stanford Canine Narcolepsy Colony. Breeding studies revealed
the genetic determinants of canine narcolepsy, an autosomal
recessive gene we termed canarc1. Emmanuel Mignot took over the
colony in 1986 and began sequencing DNA, finally isolating canarc1
in 1999.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
You might also like..
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
