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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Spinal Interneurons - Plasticity after Spinal Cord Injury (Paperback)
Loot Price: R3,015
Discovery Miles 30 150
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Spinal Interneurons - Plasticity after Spinal Cord Injury (Paperback)
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The spinal cord is comprised of four types of neurons: motor
neurons, pre-ganglionic neurons, ascending projection neurons, and
spinal interneurons. Interneurons are neurons that process
information within local circuits, and have an incredible ability
for neuroplasticity, whether due to persistent activity, neural
injury, or in response to disease. Although, by definition, their
axons are restricted to the same structure as the soma (in this
case the spinal cord), spinal interneurons are capable of sprouting
and rewiring entire neural circuits, and contribute to some
restoration of disrupted neural communication after injury to the
spinal cord (i.e., "bypassing" the lesion site). Spinal
Interneurons provides a focused overview of how scientists classify
interneurons in general, the techniques used to identify subsets of
interneurons, their roles in specific neural circuits, and the
scientific evidence for their neuroplasticity. Understanding the
capacity for neuroplasticity and identity of specific spinal
interneurons that are optimal for recovery, may help determine
cellular candidates for developing therapies. Spinal Interneurons
provides neuroscientists, clinicians, and trainees a reference book
exclusively concentrating on spinal interneurons, the techniques
and experiments employed to identify and study these cells as part
of normal and compromised neural circuits, and highlights the
therapeutic potential of these cells by presenting the relevant
pre-clinical and clinical work to date. People in industry will
also benefit from this book, which compiles the latest in
therapeutic strategies for targeting spinal interneurons, what
considerations there are for the development and use of treatments,
and how such treatments can not only be translated to the clinic,
but how existing treatments should be appropriately
reverse-translated to the bench.
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