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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 2 Role in General Diseases (Hardcover, New)
Loot Price: R3,275
Discovery Miles 32 750
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 2 Role in General Diseases (Hardcover, New)
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Total price: R3,295
Discovery Miles: 32 950
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity,
Infection, and Aging is a complete, authoritative examination of
the role of autophagy in health and disease. Understanding this
phenomenon is vital for the studies of cancer, aging,
neurodegeneration, immunology, and infectious diseases.
Comprehensive and forward thinking, this four-volume work offers a
valuable guide to cellular processes while encouraging researchers
to explore their potentially important connections. Understanding
the role of autophagy is critical, considering its association with
numerous biological processes, including cellular development and
differentiation, cancer (both antitumor and protumor functions),
immunity, infectious diseases, inflammation, maintenance of
homeostasis, response to cellular stress, and degenerative diseases
such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral
sclerosis, and prion diseases. Cell homeostasis is achieved by
balancing biosynthesis and cellular turnover. In spite of the
increasing importance of autophagy in various pathophysiological
conditions mentioned above, this process remains underestimated and
overlooked. As a consequence, its role in the initiation,
stability, maintenance, and progression of these and other diseases
(e.g., autoimmune disease) remains poorly understood. This work
will broaden the knowledge base of academic and clinical
professors, post-doctoral fellows, graduate and medical students
regarding this vital biological process. Volumes in the Series
Volume 1: Molecular Mechanisms. Elucidates autophagy's association
with numerous biological processes, including cellular development
and differentiation, cancer, immunity, infectious diseases,
inflammation, maintenance of homeostasis, response to cellular
stress, and degenerative diseases such as Alzheimer's, Parkinson's,
Huntington's, amyotrophic lateral sclerosis, and prion diseases.
Volume 2: Role in General Diseases. Describes the various aspects
of the complex process of autophagy in a myriad of devastating
human diseases, expanding from a discussion of essential autophagic
functions into the role of autophagy in proteins, pathogens,
immunity, and general diseases. Volume 3: Role in Specific
Diseases. Explores the role of autophagy in specific diseases and
developments, including: Crohn's Disease, Gaucher Disease,
Huntington's Disease, HCV infection, osteoarthritis, and liver
injury, with a full section devoted to in-depth exploration of
autophagy in tumor development and cancer, as well as the
relationship between autophagy and apoptosis. Volume 4: Mitophagy.
Presents detailed information on the role of mitophagy, the
selective autophagy of mitochondria, in health and disease, by
delivering an in-depth treatment of the molecular mechanisms
involved in mitophagy initiation and execution, as well as the role
of mitophagy in Parkinson Disease, cardiac aging, and skeletal
muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively
describes the role of autophagy in human diseases, delivering
coverage of the antitumor and protumor roles of autophagy; the
therapeutic inhibition of autophagy in cancer; and the duality of
autophagy's effects in various cardiovascular, metabolic, and
neurodegenerative disorders. Volume 6: Regulation of Autophagy and
Selective Autophagy. Provides coverage of the mechanisms of
regulation of autophagy; intracellular pathogen use of the
autophagy mechanism; the role of autophagy in host immunity; and
selective autophagy. Volume 7: Role of Autophagy in Therapeutic
Applications. Provides coverage of the latest developments in
autophagosome biogenesis and regulation; the role of autophagy in
protein quality control; the role of autophagy in apoptosis;
autophagy in the cardiovascular system; and the relationships
between autophagy and lifestyle. Volume 8: Autophagy and Human
Diseases. Reviews recent advancements in the molecular mechanisms
underlying a large number of genetic and epigenetic diseases and
abnormalities, and introduces new, more effective therapeutic
strategies, in the development of targeted drugs and programmed
cell death, providing information that will aid on preventing
detrimental inflammation. Volume 9: Necrosis and Inflammation in
Human Diseases. Emphasizes the role of Autophagy in necrosis and
inflammation, explaining in detail the molecular mechanism(s)
underlying the formation of autophagosomes, including the
progression of Omegasomes to autophagosomes.
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