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Books > Medicine > Clinical & internal medicine > Geriatric medicine
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Genetic Aberrancies and Neurodegenerative Disorders, Volume 3 (Hardcover)
Loot Price: R2,720
Discovery Miles 27 200
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Genetic Aberrancies and Neurodegenerative Disorders, Volume 3 (Hardcover)
Series: Advances in Cell Aging & Gerontology
Expected to ship within 12 - 17 working days
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" Genetic Aberrancies and Neurodegenerative Disorders" presents
critical reviews and emerging findings concerning the roles of
genetic mutations and polymorphisms in the pathogenesis of a range
of neurological disorders including Alzheimer's and Parkinson's
diseases, trinucleotide repeat disorders, stroke, epilepsy and
others. This volume, written by leading experts, brings together
fundamental information concerning the roles of inherited traits in
the pathogenesis of different neurodegenerative disorders. In
addition to providing a catalogue of the known genetic alterations
that are linked to specific neurodegenerative disorders, the
chapters detail the current state of understanding of the cellular
and biochemical mechanisms whereby the genetic aberrancies lead to
neuronal dysfunction and degeneration. The emerging picture of each
disorder, painted by pathological, biochemical and molecular
brushes, suggests that they share key mechanisms including
increased levels of oxidative stress, perturbed ion homeostasis,
mitochondrial dysfunction and apoptotic proteolytic cascades. The
existence of specific molecular defects provides the opportunity to
design experiments that can establish the precise pathogenic
mechanism of a specific mutation or genetic risk factor. The value
of this approach is exemplified by recent studies of how mutations
in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis
and how presenilin mutations result in early-onset Alzheimer's
disease. A theme developed among the different chapters is that
events that occur during aging predispose neurons to genetic
aberrancies that promote degenerative cascades, and that specific
genetic defects exert their influence on particular populations of
neurons in a disorder-specific manner. The chapters in this volume
will stimulate readers to generate new hypotheses concerning the
pathogenic mechanisms of genetic aberrancies that can be
experimentally tested.
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