The lipids of cellular membranes not only serve roles in
controlling the structure and fluidity of the membrane, but are
increasingly recognized for their roles as signalling molecules and
modifiers of membrane protein function. Recent studies described in
this volume reveal striking changes in membrane lipids during aging
and in age-related diseases such as cancer, cardiovascular disease
and neurodegenerative disorders. Lipids including inositol
phospholipids, cholesterol, sphingolipids and ceramides play
important roles in signalling cellular responses to stress and
specific stimuli such as growth factors, cytokines and
neurotransmitters. One or more of these lipid mediators has been
linked to the pathogenesis of age-related diseases.
This book provides a comprehensive review of specific membrane
lipid mediators and their roles in aging and age-related
disease.
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