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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Regulation of Immune Gene Expression (Hardcover, 1986 ed.)
Loot Price: R3,190
Discovery Miles 31 900
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Regulation of Immune Gene Expression (Hardcover, 1986 ed.)
Series: Experimental Biology and Medicine, 13
Expected to ship within 10 - 15 working days
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This book encompasses the proceedings of a conference held at
Trinity College, Oxford on September 21-25, 1985 organized by a
committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael,
and E. Simpson, and advised by many friends and colleagues. The
immune response gene workshops that took place were based on the
need to understand why certain experimental animal strains were
high responders and others were low responders. It was assumed that
identification of the immune response (Ir) genes and definition of
their products would explain high and low responder status.
Research in the ensuing years has identified the Ir gene products
involved in antibody responses as the la antigens, or MHC Class II
antigens. These proteins are now well defined as members of the
immunoglobulin gene superfamily, and their domain structure is
known. Epitopes have been defined by multiple mono clonal
antibodies and regions of hypervariability identified. Their genes
have been identified and cloned. The basic observation of high and
low responsive ness to antigen is still not understood in
mechanistic terms, however, at either the cellular or molecular
level. This is because the rate of progress in immune regulation
has been far slower than in the molecular biology of the MHC Class
II antigens. This is not surprising, since immune regulation is a
very complex field at the crossroads of many disciplines."
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