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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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PI3K and AKT Isoforms in Immunity - Mechanisms and Therapeutic Opportunities (Hardcover, 1st ed. 2022)
Loot Price: R4,310
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PI3K and AKT Isoforms in Immunity - Mechanisms and Therapeutic Opportunities (Hardcover, 1st ed. 2022)
Series: Current Topics in Microbiology and Immunology, 436
Expected to ship within 10 - 15 working days
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This book provides an essential overview of the role of
phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating
the function of immune system cells and their involvement in
disease. PI3K is a family of kinases involved in basic cellular
processes such as proliferation, migration and cell death. Recent
work has highlighted the multiple roles of PI3K classes and
subunits and their involvement in the immune response to the body's
own and foreign antigens and diseases such as cancer and
autoimmunity. This book offers a detailed introduction to the
biology of the three PI3K classes, followed by an extensive
discussion of the diverse roles of AKT and PI3K isoforms in immune
cells. Based on this knowledge, it subsequently explains in more
detail how specific isoforms are connected to immune-mediated
diseases. The book concludes by highlighting the latest advances in
the production of isoform-specific inhibitors and their use in
various human diseases. This book is intended as a reference guide
for students and researchers interested in the multifaceted aspects
of PI3K biology.
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