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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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DNA Vaccines (Paperback, Softcover reprint of hardcover 1st ed. 2006)
Loot Price: R4,514
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DNA Vaccines (Paperback, Softcover reprint of hardcover 1st ed. 2006)
Series: Methods in Molecular Medicine, 127
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In the early 1990s, almost 200 yr after Edward Jenner demonstrated
the effectiveness of the smallpox vaccine, a new paradigm for
vaccination emerged. The conventional method of vaccination
required delivery of whole pathogens or structural subunits, but in
this new approach, DNA or genetic information was administered to
elicit an immunological response. Once it was observed that plasmid
DNA delivered in vivo led to production of an encoded transgene
(1), two ground-breaking studies demonstrated that immunological
responses could be generated against antigenic transgenes via
plasmid DNA delivered by DNA vaccination (as this approach is
called) (2,3). The appe- ance of this new vaccination strategy
coincided with advances in molecular biology, which provided new
tools to study and manipulate the basic elements of an organism's
genome and also could also be applied to the design and production
of DNA vaccines. DNA Vaccines is a major updated and enhancement of
the first edition. It reviews state-of-the-art methods in DNA
vaccine technology, with chapters describing DNA vaccine design,
delivery systems, adjuvants, current appli- tions, methods of
production, and quality control. Consistent with the approach of
the Methods in Molecular Medicine series, these chapters contain
detailed practical procedures on the latest DNA vaccine technology.
The enthusiasm for DNA vaccine technology is made clear by the
number of research studies published on this topic since the
mid-1990s.
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