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Fundamentals of Neurodegeneration and Protein Misfolding Disorders (Hardcover, 1st ed. 2015)
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Fundamentals of Neurodegeneration and Protein Misfolding Disorders (Hardcover, 1st ed. 2015)
Series: Biological and Medical Physics, Biomedical Engineering
Expected to ship within 12 - 19 working days
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This unique text introduces students and researchers to the world
of misfolded proteins, toxic oligomers, and amyloid assemblages,
and the diseases of the brain that result. During the past few
years the connections between failures in protein quality control
and neurological disorders have been reinforced and strengthened by
discoveries on multiple fronts. These findings provide novel
insights on how amyloidogenic oligomers and fibrils form,
interconvert from one state to another, and propagate from cell to
cell and region to region. Starting with protein folding and
protein quality control basics, the reader will learn how misfolded
proteins can cause diseases ranging from prion diseases to
Alzheimer's disease and Parkinson's disease to Huntington's
disease, amyotrophic lateral sclerosis and frontotemporal lobar
degeneration. Authoritative but written in a clear and engaging
style, Fundamentals of Neurodegeneration and Protein Misfolding
Disorders addresses one of today's forefront areas of science and
medicine. The text emphasizes the new groundbreaking biophysical
and biochemical methods that enable molecular-level explorations
and the conceptual breakthroughs that result. It contains separate
chapters on each of the major disease classes. Special emphasis is
placed on those factors and themes that are common to the diseases,
especially failures in synaptic transmission, mitochondrial
control, and axonal transport; breakdowns in RNA processing; the
potential role of environmental factors; and the confounding
effects of neuroinflammation. The book is ideal for use in teaching
at the advanced undergraduate and graduate levels, and serves as a
comprehensive reference for a broad audience of students and
researchers in neuroscience, molecular biology, biological physics
and biomedical engineering.
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