Initially believed to be inactive molecules, glycans are now
considered essential for life, both under normal and pathological
conditions.
This volume of the series "Biology of Extracellular Matrix "
reviews the most recent findings on the role of glycans in the
development of diseases and the possible therapeutic use of this
class of molecules. It shows how the interaction of glycans with
growth factors, growth factor binding proteins, extracellular
proteases, protease inhibitors, chemokines, morphogens, and
adhesive proteins regulates inflammation, infection, cancer,
atherosclerosis, thrombosis and embryonic stem cell biology.
Furthermore, an extensive survey about the structure and
pharmacological effects of unique marine glycosaminoglycans is
discussed as well as the possibility of using these glycans as
therapeutic agents.
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