It covers all aspects of DC generation, function, survival and
antitumor activity in the tumor environment both in vivo and in
experimental in vitro systems. The goal in focusing on a spectrum
of issues related to DC in cancer is to provide an extensive and
expansive review rather than a collection of independent analyses
from different authors.
Specific topics to be covered include analysis of DC behavior in
the tumor microenvironment, including endogenous and exogenous DC,
multiple DC populations, molecular pathways responsible for DC
dysfunction, tumor-derived factors altering DC polarization and
activation, mechanisms of DC alterations, and the role of DC in
tumor escape from immune recognition and elimination. Furthermore,
additional chapters provide extensive analysis of the consequences
of cancer therapy on the DC system and how aging impacts DC
function in the tumor microenvironment. Finally, chapters are
included examining strengths and pitfalls of current methodologies
for generating DC from cancer patients for therapeutic purposes and
on the role of tumor-mediated modulation of the DC system in cancer
immunotherapy.
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