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Insights into Human Neurodegeneration: Lessons Learnt from Drosophila (Hardcover, 1st ed. 2019)
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Insights into Human Neurodegeneration: Lessons Learnt from Drosophila (Hardcover, 1st ed. 2019)
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This book is aimed at generating an updated reservoir of scientific
endeavors undertaken to unravel the complicated yet intriguing
topic of neurodegeneration. Scientists from Europe, USA and India
who are experts in the field of neurodegenerative diseases have
contributed to this book. This book will help readers gain insight
into the recent knowledge obtained from Drosophila model, in
understanding the molecular mechanisms underlying neurodegenerative
disorders and also unravel novel scopes for therapeutic
interventions. Different methodologies available to create
humanized fly models that faithfully reflects the pathogenicities
associated with particular disorders have been described here. It
also includes information on the exciting area of neural stem
cells. A brief discussion on neurofibrillary tangles, precedes the
elaborate description of lessons learnt from Drosophila about
Alzheimer's, Parkinson's, Spinomuscular Atrophy, Huntington's
diseases, RNA expansion disorders and Hereditary Spastic
Paraplegia. We have concluded the book with the use of Drosophila
for identifying pharmacological therapies for neurodegenerative
disorders. The wide range of topics covered here will not only be
relevant for beginners who are new to the concept of the extensive
utility of Drosophila as a model to study human disorders; but will
also be an important contribution to the scientific community, with
an insight into the paradigm shift in our understanding of
neurodegenerative disorders. Completed with informative tables and
communicative illustrations this book will keep the readers glued
and intrigued. We have comprehensively anthologized the lessons
learnt on neurodegeneration from Drosophila and have thus provided
an insight into the multidimensional aspects of pathogenicities of
majority of the neurodegenerative disorders.
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