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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Murine Models, Energy Balance, and Cancer (Paperback, Softcover reprint of the original 1st ed. 2015)
Loot Price: R3,909
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Murine Models, Energy Balance, and Cancer (Paperback, Softcover reprint of the original 1st ed. 2015)
Series: Energy Balance and Cancer, 10
Expected to ship within 10 - 15 working days
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This volume provides a transdisciplinary and translational review
of many of the leading murine models used to study the mechanisms,
mediators and biomarkers linking energy balance to cancer. It
provides a review of murine models that should be of interest to
basic, clinical and applied research investigators as well as
nutrition scientists and students that work in cancer prevention,
cancer control and treatment. The worldwide obesity pandemic has
been extensively studied by epidemiologic and observational studies
and even, in some cases, by randomized controlled trials. However,
the development and control of obesity, its comorbidities and its
impact on cancer usually occurs over such long periods that it is
difficult, if not impossible to conduct randomized controlled
trials in humans to investigate environmental contributions to
obesity, energy balance and their impact on cancer. In contrast,
model organisms, especially mice and rats, provide valuable assets
for performing these studies under rigorously controlled conditions
and in sufficient numbers to provide statistically significant
results. In this volume, many of the leading and new murine models
used to study the mechanisms and mediators linking cancer with
obesity, sleep, exercise, their modification by environment and how
they may continue to be used to further elucidate these relations
as well as to explore preclinical aspects of prevention and/or
therapeutic intervention are considered. This volume provides an
important compilation and analysis of major experimental systems
and principles for further preclinical research with translational
impact on energy balance and cancer.
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